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KMID : 1143220210640060532
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Obstetrics & Gynecology Science
2021 Volume.64 No. 6 p.532 ~ p.539
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Association between decreased ovarian reserve and poor oocyte quality
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Scantamburlo Viviane Margareth
von Linsingen Renate
Centa Lidio Jair Ribas
Toso Kahisa Fontana Dal
Scaraboto Debora
Araujo Edward Junior
Kulak Jaime Junior
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Abstract
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Objective: To analyze the association between oocyte quality and decreased ovarian reserve (DOR) markers in young women undergoing controlled ovarian stimulation (COS).
Methods: This retrospective study included 49 patients classified as having DOR based on anti-Mullerian hormone (AMH) levels, follicle-stimulating hormone (FSH) levels, or antral follicle counts (AFCs; <10). Images of all obtained oocytes were analyzed, and oocyte quality was classified according to maturity and morphology. The COS protocol utilized gonadotropin (FSH and/or human menopausal gonadotropin [hMG]) doses ranging from 150 to 300 IU/day. The Student’s t test or Mann-Whitney test was used to compare the groups. Spearman’s coefficients were estimated to verify the correlation between the administered dose of FSH/hMG and the number of mature oocytes. To evaluate the association between patient- and oocyte-related variables, logistic regression models were adjusted.
Results: Women with DOR classified according to FSH level had more immature oocytes (P<0.001). Women with DOR according to AMH had fewer mature oocytes and increased basal FSH levels (P<0.001). Women with DOR according to AFC had an increased risk of abnormally shaped oocytes (P=0.035).
Conclusion: This study showed that DOR based on AMH levels, FSH levels, and AFC was associated with poorer quality oocytes in young women who underwent COS.
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KEYWORD
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Infertility, Oocyte quality, Ovarian reserve, Controlled ovarian stimulation, Decreased ovarian reserve
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